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5f-PB-22

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Interactions
Tolerance
Legality
5f-PB-22 molecule structure5f-PB-22 molecule structure
Open in Piru

5F-PB-22 is a synthetic cannabinoid1 and acts as an agonist at CB1 receptors2. It has a pronounced sedating aspect and, as is common with synthetic cannabinoids, a fast onset. Its molecular structure appears to reflect deliberate application of structure–activity relationships within the indole cannabinoid class.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold1 mg
Light1-3 mg
Moderate3-5 mg
Strong5-8 mg
Heavy8+ mg

Due to the limited pharmacological data available for this compound, users should begin with the lowest possible dose and increase gradually to assess individual sensitivity.

Duration

Onset5-10 minutes
After Effects30-60 minutes
Total60-90 minutes

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Perception of increased weight or Perception of decreased weightIncreased heart rate

Cognitive

Thought decelerationConceptual thinkingMindfulnessInformation processing suppressionDream suppressionImmersion enhancement

Visual

Colour enhancementAcuity suppression

Auditory

Enhancements
Forked from Subjective Effect Documentation work byJosie Kins September 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → orange2
Mecke(ME)
white → brown2
Mandelin(MD)
yellow2 → green3 → brown3
Liebermann(LB)
white → brown3
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Pharmacology

Pharmacodynamics

5F-PB-22 acts as a full agonist at cannabinoid CB1 and CB2 receptors.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

5F-PB-22 is classified as habit-forming.

Toxicity

Lethal Dosage

Several deaths were associated with 5F-PB-22 use6; no lethal-dose estimate or exposure conditions are specified.

History & Culture

5F-PB-22 is a designer drug7 whose structure appears to have been developed with an understanding of structure–activity relationships among indole cannabinoids.

Legality

Legality not written up yet

References

Citations

  1. Differentiation and identification of 5F-PB-22 and its isomers. Forensic Science International (2017). https://doi.org/10.1016/j.forsciint.2017.08.0091
  2. Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135. Neuropharmacology (2016). https://doi.org/10.1016/j.neuropharm.2015.11.0171
  3. 5F-PB-22. WHO Expert Committee on Drug Dependence Information Repository (2017). https://ecddrepository.org/en/5f-pb-221
  4. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists. Springer (2018). https://doi.org/10.1007/164_2018_14412
  5. Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chemical Neuroscience / PubMed (2015). https://doi.org/10.1021/acschemneuro.5b001071
  6. Four Postmortem Case Reports with Quantitative Detection of the Synthetic Cannabinoid, 5F-PB-22. Journal of Analytical Toxicology / PubMed Central (2014). https://doi.org/10.1093/jat/bku0481
  7. Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.. Zenodo (2015). https://doi.org/10.1021/acschemneuro.5b001071

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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