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5f-Akb48

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Interactions
Tolerance
Legality
5f-Akb48 molecule structure5f-Akb48 molecule structure
Open in Piru

5f-Akb48 is a synthetic cannabinoid receptor agonist1 with subjective effects somewhat similar to cannabis. It was first identified in South Korea2 and has been sold online1 in herbal incense and herbal mixture products marketed under various brand names1. Herbs containing the substance are smoked for recreational use1, and it is generally regarded as very short-acting, although it can sometimes cause a very long afterglow1.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold500 µg
Light500-1000 µg
Strong1000-2500 µg
Heavy2500+ µg

Duration

Onset20 seconds
Total2 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Perception of increased weight or Perception of decreased weightChanges in gravityVasodilation

Cognitive

ParanoiaCurrent mind state enhancementThought connectivityThought decelerationConceptual thinkingMindfulnessInformation processing suppressionDream suppression

Auditory

Enhancements
Forked from Subjective Effect Documentation work byJosie Kins September 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mandelin(MD)
yellow2 → orange2 → black3
Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Ehrlich(EH)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

5F-APINACA acts as a full agonist at cannabinoid CB1 receptors and as an agonist at CB2 receptors, with high binding affinity at both targets.1

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

5F-AKB48 is considered habit-forming, supporting concern for psychological reinforcement.

Toxicity

Lethal Dosage

The extracted experience report warns that severe distress occurred after only a couple of inhalations and mentions tragic incidents associated with related blends, but gives no lethal dose.

central nervous system

A severe acute reaction included extreme fear, panic, dread, paranoia, and incapacitating distress.

Psychosis Risk

Moderate

The extracted report describes acute paranoia and panic after limited use, but does not document clinical psychosis.

History & Culture

5F-APINACA was first identified in South Korea3 and was later sold online as a designer drug. In the United Kingdom, it was encountered in head-shop smoking mixtures marketed under brand names such as “Magic Dragon.” Media reports subsequently described tragic incidents associated with some blends containing related compounds, reflecting their use as products presented as cannabis substitutes.

Legality

Legality not written up yet

References

Citations

  1. 5F-APINACA (5F-AKB-48) Critical Review Report. WHO Expert Committee on Drug Dependence (2016). https://ecddrepository.org/sites/default/files/4.10_5f-apinaca_critreview.pdf123456
  2. Schedules of Controlled Substances: Temporary Placement of Certain Synthetic Cannabinoids. Federal Register (2019). https://www.govinfo.gov/content/pkg/FR-2019-04-08/pdf/2019-06853.pdf1
  3. Schedules of Controlled Substances: Placement of Six Synthetic Cannabinoids Into Schedule I. Federal Register (2019). https://public-inspection.federalregister.gov/2019-06853.pdf1

Further Reading

  1. Holm et al. 2014 - Metabolites of 5F‐AKB‐48, a synthetic cannabinoid receptor agonist, identified in human urine and liver microsomal preparations using liquid chromatography high‐resolution mass spectrometry

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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