Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
5-MeO-MT
5-MeO-MT is described as a tryptamine with psychedelic and entactogenic effects. It is described as structurally related to α-methyltryptamine and is reported to be highly potent, with occasional distribution on blotters. The substance was synthesized1, and its psychedelic effects in humans were first observed in 1976. It may act as a monoamine oxidase inhibitor, so caution is advised; rare reports describe it being sold as LSD.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Hospitalizations have been reported at oral doses as low as 8 mg, indicating a narrow margin of safety and the need for extreme caution with dosing.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
In the cited in vitro study, 5-MeO-AMT showed agonist activity at 5-HT2A and 5-HT2B receptors. It was described as the most potent 5-HT2A receptor ligand and agonist among the tryptamines evaluated in that study and the previous studies discussed by its authors, with an in vitro 5-HT2A EC50 of 2 nM and a 5-HT2B EC50 of 4 nM. 5-MeO-AMT was a very weak monoamine transporter inhibitor relative to its much higher potency at 5-HT2A and induced transporter-mediated release of dopamine and serotonin. It is also a weak MAO-A inhibitor.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Toxicity
At least one death has been documented from overdose. Particularly sensitive individuals can experience overdose symptoms at doses as low as 20 mg, which falls within the normal range for most users. Hospitalizations have occurred at doses as low as 8 mg. The compound appears to have a narrow margin of safety, and oral consumption seems safer than insufflation.
Cardiac arrhythmia has been noted in overdose cases, likely due to the compound's sympathomimetic effects.
Seizure Risk
Seizures have been noted in overdose cases. The seizure risk appears to be associated with the compound's sympathomimetic effects and may occur at doses that some users consider within normal range.
History & Culture
Legality
References
Citations
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed: this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 5-MeO-MT article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.
