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4-Benzylpiperidine

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
4-Benzylpiperidine molecule structure4-Benzylpiperidine molecule structure
4-PMPDOpen in Piru
Psychoactive Class
Stimulant
Chemical Class
PiperidineBenzylpiperidine

4-Benzylpiperidine is a stimulant belonging to the piperidine and benzylpiperidine chemical classes. It is used as a research chemical in scientific studies and has been encountered as a designer drug. It may be dangerous in overdose.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~75 mg
Light75-125 mg
Moderate125-200 mg
Strong200-350 mg
Heavy350+ mg

Duration

Onset10-45 minutes
Total2-5 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

4-Benzylpiperidine acts as a monoamine releasing agent, with its strongest reported releasing activity at norepinephrine. It also releases dopamine, with 20- to 48-fold selectivity for dopamine release over serotonin release. In addition, it weakly inhibits both MAO-A and MAO-B.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Described as habit-forming, suggesting some potential for psychological dependence, though human use data is limited.

Toxicity

Lethal Dosage

Potentially dangerous in overdose given the combination of MAOI and monoamine releasing properties.

Psychosis Risk

Visual and auditory hallucinations have been reported as adverse effects.

History & Culture

4-Benzylpiperidine was used in scientific research1 and was also encountered as a designer drug.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: 4-Benzylpiperidine user experiences megathread
  2. Wikipedia

Citations

  1. Formulation and evaluation of 4-benzylpiperidine drug-in-adhesive matrix type transdermal patch. International Journal of Pharmaceutics (2018). https://doi.org/10.1016/j.ijpharm.2018.08.0331

Further Reading

  1. Biosynth - MAO-A/B IC50 values
  2. ChemicalBook - Onset, duration and discrimination study summary
  3. Drugs-Forum: 4-PMPD experience report and theory
  4. Reddit: r/Nootropics - 4-Benzylpiperidine user experiences
  5. Reddit: r/Nootropics - 4-PMPD discussion thread
  6. ScienceDirect: Structural requirements for modulating 4-benzylpiperidine uptake (SAR)
  7. ScienceDirect: Transdermal formulation study showing rapid onset and short duration
  8. Sigma-Aldrich - Dopamine-selective releaser product sheet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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