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Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
HighDiscrimination studies have found 3,4-CTMP to be more addictive than cocaine. Reports compare its abuse potential to amphetamine or MDMA, citing limited tolerance, euphoric effects, and dopamine-transporter activity.
Toxicity
Chronic use or high doses may cause serious cardiovascular effects including pulmonary hypertension, heart valve fibrosis, abnormal heartbeat, and severe vasoconstriction; these risks are particularly concerning due to the substance's potent 5-HT2B receptor agonism.
5-HT2B receptor agonism may contribute to pulmonary hypertension, which can present with breathing difficulty, lightheadedness, and related cardiovascular warning signs. This hazard may become severe or fatal, particularly with high doses or long-term use.
Insufflation is reported to be painful and potentially extremely caustic due to low water solubility preventing ready absorption through nasal mucus membranes.
Psychosis Risk
Prolonged misuse can result in stimulant psychosis, especially when excessive dosing is combined with sleep deprivation.
History & Culture
Legality
By Country
References
Citations
Article Status
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