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25-DMA
25-DMA is a psychoactive substituted amphetamine and the simplest member of the DOx family. It reportedly lacks notable psychedelic effects1 and is primarily used as a precursor in the synthesis of other psychedelic amphetamines, including DOB, DOI, and DON.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold10 mg
Light10-40 mg
Moderate40-80 mg
Strong80-200 mg
Heavy200+ mg
Duration
Total6-8 hours
Subjective Effects
Subjective Effects not written up yet
Pharmacology
Pharmacology not written up yet
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Tolerance to the effects of 25-DMA develops over several days following ingestion.
Tolerance returns to baseline within approximately 7–10 days if no further doses are taken.
Tolerance falls to approximately 50% within 3–5 days if no further doses are taken.
Possible but unlikely cross-tolerance with all psychedelics, Possible cross-tolerance with stimulants
Harm Potential
Addiction & Dependence
Psychological
LowLike many psychedelic substances, 2,5-DMA is not generally regarded as habit-forming, and interest in repeated use may decline with experience. Its stimulant qualities, however, may create some risk of psychological dependence similar to other stimulants.
History & Culture
2,5-DMA was first synthesized in 1939 by Richard Baltzly and Johannes S. Buck in Tuckahoe, New York. Alexander Shulgin later explored its effects in humans and published his findings in PiHKAL (Phenethylamines I Have Known and Loved).2…
Legality
By Country
Illegal4
United StatesIllegal2,5-DMA is expressly listed as 2,5-dimethoxyamphetamine in federal Schedule I under 21 C.F.R. § 1308.11(d)(4), with controlled-substance code 7396; the DEA also identifies DMA and 2,5-DMA as other names. Because it is itself a controlled substance, it is excluded from the statutory definition of a controlled substance analogue, so analogue treatment is not the basis of its federal classification. Subject to the authorizations and exceptions in the Controlled Substances Act, federal law prohibits its possession, manufacture, distribution, dispensing, and possession with intent to manufacture, distribute, or dispense. This classification concerns federal law only and does not establish its status under state, territorial, District of Columbia, or local law.
GermanyIllegalGesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG), Anlage I (zu § 1 Abs. 1)34567
2,5-DMA is listed by the exact name Dimethoxyamfetamin (DMA), chemically identified as 1-(2,5-Dimethoxyphenyl)propan-2-ylazan, in Anlage I of the Betäubungsmittelgesetz (BtMG). Anlage I classifies it as a non-marketable narcotic drug, although the Federal Institute may exceptionally authorize it for scientific or other public-interest purposes. Under § 29(1) BtMG, unauthorized production, trade, import, export, sale, supply, acquisition, procurement, and possession without written acquisition authorization are punishable by up to five years' imprisonment or a fine. The NpSG is not the operative classification because it excludes narcotic drugs listed under § 1(1) BtMG.
SwitzerlandIllegalVerordnung des EDI vom 30. Mai 2011 über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (BetmVV-EDI), Anhang 5, Verzeichnis d8910
The current BetmVV-EDI lists 2,5-Dimethoxyamphetamin (DMA) in Annex 5, Verzeichnis d, as a prohibited controlled substance. Unauthorized cultivation, production, storage, shipment, transport, import, export, transit, sale, prescribing, supply, placing on the market, possession, and acquisition are punishable under Article 19(1) of the BetmG by imprisonment for up to three years or a monetary penalty. The Federal Office of Public Health may grant exceptional authorizations for handling Verzeichnis d substances.
United KingdomIllegal (analog/blanket ban)2,5-DMA is covered as a Class A drug by the generic phenethylamine provision in Part I of Schedule 2 to the Misuse of Drugs Act 1971. It is 1-(2,5-dimethoxyphenyl)propan-2-amine, an alpha-methylphenethylamine bearing two methoxy ring substituents, and falls within paragraph 1(c)'s structural class. Neither the methoxyphenamine exclusion nor the exclusion for compounds already named in paragraph 1(a) applies. This phenethylamine class has been controlled since 20 September 1977. Unauthorized possession, production, supply, and offering to supply are prohibited under sections 4 and 5 of the Act.
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