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2-MeO-Ketamine

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
Harm Potential
Legality
2-MeO-Ketamine molecule structure2-MeO-Ketamine molecule structure
2-Methoxyketamine
Methoxyketamine, DinoKet, 2-MeO-2-deschloroketamineOpen in Piru
Psychoactive Class
DissociativeHallucinogen
Chemical Class
Arylcyclohexylamine

2-MeO-Ketamine is an arylcyclohexylamine dissociative and hallucinogen first reported in 1963. It is a ketamine analogue1 in which a methoxy group replaces the chlorine atom. It produces sedative and hallucinogenic effects, with anesthetic effects at high doses, and is reported to have dissociative effects similar to ketamine. Its potency is slightly lower than ketamine's. It can be habit-forming and is reported to be extremely rare.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-15 mg
Light15-60 mg
Moderate60-130 mg
Strong130+ mg

The 60-130 mg range is common, and the strong range is 130-200 mg+.

Duration

Onset10-20 minutes
After Effects2-4 hours
Total1-2 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow1 → orange1 → red1 → pink1
Mecke(ME)
white → yellow2 → orange2 → red2
Mandelin(MD)
yellow2 → red2 → brown2
Liebermann(LB)
white → brown2
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Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

2-MeO-Ketamine is a designer arylcyclohexylamine first reported in 1963. It is described as a ketamine analog in which ketamine's chlorine atom is replaced by a methoxy group.

Early report

The first report of 2-MeO-Ketamine dates to 1963, with synthesis work described as involving rearrangement of an amino ketone.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: The Big & Dandy Methoxyketamine Thread
  2. Erowid: Ketamine Pharmacology and Dosage
  3. TripSit Factsheet: Methoxyketamine
  4. Wikipedia: 2-MeO-Ketamine

Citations

  1. Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. Drug Testing and Analysis (2016). https://doi.org/10.1002/dta.18611

Further Reading

  1. Drugs-Forum: Methoxyketamine
  2. Roth et al. 2013 - The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

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