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2-Chloroephenidine

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Interactions

Harm Potential

History & Culture

2-Chloroephenidine

2-Cl-Eph, 2-Cl-diphenidine

Psychoactive Class

Dissociative Hallucinogen

Chemical Class

Diarylethylamine (substituted)

2-Chloroephenidine is a dissociative research chemical of the diarylethylamine class and a structural analogue of ephenidine. Very little is known about this compound's pharmacology, toxicity, or subjective effect profile.¹ It is believed to produce dissociative effects and is reported to be slightly less potent than its parent compound. Due to the near-total absence of research or documented human use, it should be approached with extreme caution.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~100 mg

Light100-130 mg

Moderate130-175 mg

Strong175-200 mg

Heavy200+ mg

Duration

Onset10-30 minutes

After Effects1-6 hours

Total3-6 hours

Subjective Effects

Very little is documented about this compound. As a structural analogue of ephenidine, it is considered likely to produce dissociative effects, with slightly lower potency than the parent compound.

Pharmacology

Pharmacodynamics

Binding Sites

NMDA receptor antagonistnoncompetitive

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check

TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Dissociatives, NMDA receptor antagonists

Harm Potential

Harm Potential not written up yet

History & Culture

History & Culture not written up yet

Legality

International

As of 23 August 2026, 2-Chloroephenidine (2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine) is not named or chemically designated in the current complete INCB Yellow, Green or Red Lists. The Green List instead places diphenidine, chemically designated as 1-(1,2-Diphenylethyl)piperidine, in Schedule II. That entry does not cover 2-Chloroephenidine: diphenidine contains a piperidine ring, while 2-Chloroephenidine is an open-chain N-ethylamine with an ortho-chloro substituent. The Green List's stereoisomer guidance applies within the specific chemical designation of a scheduled substance, not to constitutionally distinct analogues. INCB's March 2026 notice adds only MDMB-FUBINACA to Schedule II, with effect from 25 November 2026, and does not name 2-Chloroephenidine. Accordingly, the current INCB materials establish no scheduling of 2-Chloroephenidine under the 1961, 1971 or 1988 conventions.

By Country

ArgentinaIllegal (analog/blanket ban)Estupefaciente

Decreto 560/2019, artículo 2 y Anexo II (Grupo 15: Fenetilaminas sustituidas)²³

Argentina controls 2-Chloroephenidine through the substituted-phenethylamine chemical group in Annex II of Decree 560/2019 rather than by individual name. Its N-ethyl group, aryl substitution, and ortho-chloro aromatic substitution match the Group 15 allowances for C1–C8 alkyl at R1/R1′, aryl at R2, and halogen at R4. Article 2 treats substances within an Annex II chemical group as estupefacientes for article 77 of the Penal Code.

AustriaIllegal (analog/blanket ban)NPS structure class

Neue-Psychoaktive-Substanzen-Verordnung (NPSV), § 1 Abs. 1 Z 2 and Abs. 2, Anlage II Z 2; Neue-Psychoaktive-Substanzen-Gesetz (NPSG), § 4⁷⁸⁹¹⁰

Austria's NPSV treats every compound derivable from a phenethylamine core, including compounds bearing the substituent structures listed in § 1(2), as a new psychoactive substance. The official NCATS record identifies 2-chloroephenidine as 2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine, placing it within that structure-defined class rather than requiring an exact-name listing. Section 4 NPSG criminalizes manufacture, import, export, transfer, or procurement for another when done to obtain an advantage and with intent that the substance be used for a psychoactive effect.

CanadaIllegal (analog/blanket ban)Schedule I analogue

Controlled Drugs and Substances Act, Schedule I, item 24¹⁴

Canada's Schedule I entry for MT-45 expressly includes its derivatives, isomers, and analogues and identifies ephenidine as an included analogue. The Act defines an analogue as a substance having a substantially similar chemical structure; 2-Chloroephenidine is the chlorine-substituted derivative of the listed ephenidine structure, so unauthorized possession is prohibited under the Schedule I regime.

NetherlandsIllegal (analog/blanket ban)List IA Group 1

Opium Act, article 2a and List IA group 1, as inserted by Staatsblad 2025, 32¹⁷

The Netherlands' List IA group 1 covers substances derived from a 2-phenylethan-1-amine structure, with chlorine on the ring, an ethyl substituent on nitrogen, and a phenyl substituent on the aminoethyl chain all permitted by the definition. Article 2a prohibits import, export, preparation, sale, supply, possession, and manufacture of substances within the listed group, which encompasses 2-Chloroephenidine.

RussiaIllegal (analog/blanket ban)List I derivative

Resolution of the Government of the Russian Federation No. 681 of 30 June 1998, List I (as amended through Resolution No. 880 of 11 June 2025)¹⁰²²²³

Russia's List I prohibits circulation of N-methyl-1,2-diphenylethylamine and its derivatives. NCATS identifies 2-chloro-ephenidine as 2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine; relative to the listed parent, its N-ethyl chain and ring chlorine result from formal substitutions of hydrogen permitted by note 6's derivative definition, placing it within the controlled derivative class rather than naming it separately.

South AfricaIllegal (analog/blanket ban)Schedule 7 homologue

Medicines and Related Substances Act 101 of 1965, section 22A and Schedule 7^31323334

The 1,2-diarylethylamine represented by the supplied 2-Cl-Eph and 2-Cl-diphenidine names is covered through South Africa's Schedule 7 homologue rule rather than an individual 2-chloroephenidine listing. Schedule 7 names diphenidine and extends to chemically related substances that incorporate a similar structural fragment or exhibit similar pharmacodynamic properties; the official ACMD review identifies ephenidine and 2-chlorodiphenidine as related 1,2-diarylethylamine variants of diphenidine. Section 22A prohibits acquiring, using, possessing, manufacturing, or supplying a Schedule 7 substance without a Director-General permit.

AustraliaIllegal (analog/blanket ban)Schedule 9 derivative

Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, section 7 and Schedule 9⁴⁵⁶

Australia's current Poisons Standard lists ephenidine in Schedule 9 and provides that a reference to a scheduled substance includes every derivative unless a contrary intention appears. PubChem identifies this compound as 2-Chloro-ephenidine, so it is covered as the chloro derivative of the Schedule 9 entry rather than by an exact-name listing. Schedule 9 classifies substances whose manufacture, possession, supply or use should be prohibited except for approved medical, scientific, analytical, teaching or training purposes; implementation occurs through State and Territory law.

BrazilIllegal (analog/blanket ban)Lista F2

Portaria SVS/MS nº 344/1998, Anexo I, Lista F2, item a(100) and Adendo 1.1, as republished by RDC Anvisa nº 1.036/2026^11121013

2-Chloro-ephenidine is controlled in Brazil as a constitutional isomer of clobenzorex: NIH/NCATS records give both compounds the molecular formula C16H18ClN while showing different structures. The current Annex I of Portaria SVS/MS nº 344/1998 names clobenzorex in Lista F2 and extends that list's controls to all salts and isomers whenever their existence is possible. Lista F comprises substances whose use is proscribed in Brazil; the annex exempts an unlisted isomer only when it is a component of a medicine registered with Anvisa.

GermanyIllegal (analog/blanket ban)NpSG Group 1

Neue-psychoaktive-Stoffe-Gesetz (NpSG), section 3 and Annex 1 group 1¹⁵¹⁶

Germany's NpSG group 1 covers compounds derived from a 2-phenylethan-1-amine core, including N-ethyl substitution, chlorine substitution on a phenyl ring, and phenyl substitution on either carbon of the aminoethyl side chain within the stated limits. This structural definition encompasses 2-Chloroephenidine, and section 3 prohibits unauthorized trade, manufacture, import, export, acquisition, and possession.

PolandIllegal (analog/blanket ban)I-NPS

Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych, załącznik nr 3 część 2 (Dz.U. 2024 poz. 1139, as amended by Dz.U. 2025 poz. 598 and Dz.U. 2026 poz. 934)^1018192021

The U.S. National Center for Advancing Translational Sciences identifies 2-chloro-ephenidine as 2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine, with formula C16H18ClN and molecular weight 259.774. Poland's Annex 3 group I-NPS covers 2-phenylethylamine derivatives up to 500 u and permits chlorine on the phenyl element, an alkyl substituent at nitrogen, and a phenyl substituent on the side-chain element, placing this compound within the structural class rather than listing it by name. Article 62b of the Act on Counteracting Drug Addiction penalizes unlawful possession of a new psychoactive substance and provides higher penalties when a significant quantity is involved. The 2025 amendment does not alter group I-NPS, while the 2026 amendment limits specified ring closures to aliphatic rings without affecting this acyclic structure.

SingaporeIllegal (analog/blanket ban)Psychoactive substance

Misuse of Drugs Act 1973, sections 2 and 11I^{2410252627282930}

The Slovenian Police National Forensic Laboratory identifies 2-Chloro-Ephenidine in an official forensic poster as a novel NPS, while the U.S. NIH/NCATS substance record gives its preferred chemical name as 2-(2-chlorophenyl)-N-ethyl-1-phenylethylamine. It is not named in Singapore's current First Schedule. Singapore's Misuse of Drugs Act 1973 defines a psychoactive substance by its capacity to stimulate or depress the central nervous system and affect mental functioning or emotional state; CNB states that unlisted NPS with that capacity are dealt with as psychoactive substances. Section 11I makes unauthorised possession or consumption an offence, subject to a defence for possession for a legitimate purpose other than human consumption.

United KingdomIllegal (analog/blanket ban)Psychoactive substance

Psychoactive Substances Act 2016, sections 2 and 5³⁵³⁶

The Psychoactive Substances Act covers any non-exempt substance capable of producing a psychoactive effect by stimulating or depressing the central nervous system. Supplying or offering to supply 2-Chloroephenidine for consumption for its psychoactive effects is an offence; ordinary possession outside a custodial institution is not generally criminalized by this Act.

References

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Citations

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Not yet reviewed — this article is pending editorial review by Lyrea.

2-Chloroephenidine

This article is a stubmissing:

Interactions

Harm Potential

History & Culture

2-Chloroephenidine

2-Cl-Eph, 2-Cl-diphenidine

Psychoactive Class

Dissociative Hallucinogen

Chemical Class

Diarylethylamine (substituted)